Phthalazinone pyrazole

中文名	Phthalazinone pyrazole
英文名	Phthalazinone pyrazole
别名	化合物PHTHALAZINONE PYRAZOLE
英文别名	Phthalazinone pyrazole Phthalazinone pyrazole Exclusive 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1-one 4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2-phenyl-2H-phthalazin-1-one 1(2H)-Phthalazinone, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-
CAS	880487-62-7
化学式	C18H15N5O
分子量	317.34
溶解度	在DMSO中 ≤ 0.15 mg/ml; 在二甲基甲酰胺中 ≤ 0.25 mg/ml
存储条件	-20℃
产品用途	Phthalazinone pyrazole is potent, selective, and orally bioavailable inhibitor of Aurora-A kinase [1]. The Aurora protein kinase family consists of Aurora-A, -B and –C. The Aurora kinases are important group of enzymes involved in controlling several aspects of cell division in mammalian cells. Dysfunction of these kinases has been associated with a failure to maintain a stable chromosome content, a state that can contribute to tumourigenesis. Aurora-A is overexpressed in a variety of tumor types and displays oncogenic activity .
参考资料展开查看	[1] Prime M E, Courtney S M, Brookfield F A, et al. Phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of Aurora-A kinase[J]. Journal of medicinal chemistry, 2010, 54(1): 312-319.[2] Vader G, Lens S M A. The Aurora kinase family in cell division and cancer[J]. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 2008, 1786(1): 60-72.

Phthalazinone pyrazole - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	3.151 ml	15.756 ml	31.512 ml
5 mM	0.63 ml	3.151 ml	6.302 ml
10 mM	0.315 ml	1.576 ml	3.151 ml
5 mM	0.063 ml	0.315 ml	0.63 ml

最后更新：2024-01-02 23:10:35

北京索莱宝科技有限公司

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产品名: Phthalazinone pyrazole 去供应商网站查看询盘
CAS: 880487-62-7
产地: 北京
包装: 1mg(瓶)
规格: IPA11050-1mg
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上海麦克林生化科技股份有限公司

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产品名: Phthalazinone pyrazole 去供应商网站查看询盘
CAS: 880487-62-7
产地: 上海
规格: P912935
价格: 5mg-5566
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上海源叶生物科技有限公司

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产品名: Phthalazinone pyrazole 去供应商网站查看询盘
CAS: 880487-62-7
产地: 上海
规格: 98%
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