Phthalazinone pyrazole
Phthalazinone pyrazole(Phthalazinone pyrazole)
CAS: 880487-62-7
化学式: C18H15N5O
| 中文名 | Phthalazinone pyrazole |
| 英文名 | Phthalazinone pyrazole |
| 别名 | 化合物PHTHALAZINONE PYRAZOLE |
| 英文别名 | Phthalazinone pyrazole Phthalazinone pyrazole Exclusive 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1-one 4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2-phenyl-2H-phthalazin-1-one 1(2H)-Phthalazinone, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl- |
| CAS | 880487-62-7 |
| 化学式 | C18H15N5O |
| 分子量 | 317.34 |
| 溶解度 | 在DMSO中 ≤ 0.15 mg/ml; 在二甲基甲酰胺中 ≤ 0.25 mg/ml |
| 存储条件 | -20℃ |
| 产品用途 | Phthalazinone pyrazole is potent, selective, and orally bioavailable inhibitor of Aurora-A kinase [1]. The Aurora protein kinase family consists of Aurora-A, -B and –C. The Aurora kinases are important group of enzymes involved in controlling several aspects of cell division in mammalian cells. Dysfunction of these kinases has been associated with a failure to maintain a stable chromosome content, a state that can contribute to tumourigenesis. Aurora-A is overexpressed in a variety of tumor types and displays oncogenic activity . |
| 参考资料 展开查看 | [1] Prime M E, Courtney S M, Brookfield F A, et al. Phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of Aurora-A kinase[J]. Journal of medicinal chemistry, 2010, 54(1): 312-319.[2] Vader G, Lens S M A. The Aurora kinase family in cell division and cancer[J]. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 2008, 1786(1): 60-72. |
Phthalazinone pyrazole - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.151 ml | 15.756 ml | 31.512 ml |
| 5 mM | 0.63 ml | 3.151 ml | 6.302 ml |
| 10 mM | 0.315 ml | 1.576 ml | 3.151 ml |
| 5 mM | 0.063 ml | 0.315 ml | 0.63 ml |
最后更新：2024-01-02 23:10:35
供应商列表
现货供应
产品名: Phthalazinone pyrazole 去供应商网站查看 询盘CAS: 880487-62-7
产地: 上海
规格: P912935
价格: 5mg-5566
库存: 7天内发货
电话: 13816333479/13918391375
手机: 13816333479/13918391375
电子邮件: wangrui@macklin.cn
QQ: 2885703204/285395191
微信: 19863730987/13918391375
现货供应
产品名: Phthalazinone pyrazole 去供应商网站查看 询盘CAS: 880487-62-7
产地: 上海
规格: 98%
价格: 5mg 650,10mg 1100,25mg 2000,100mg 6000
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: Phthalazinone pyrazole 98% MedMol 货号：S88209
现货供应
产品名: Phthalazinone pyrazole 去供应商网站查看 询盘CAS: 880487-62-7
产地: 上海
规格: P912935
价格: 5mg-5566
库存: 7天内发货
电话: 13816333479/13918391375
手机: 13816333479/13918391375
电子邮件: wangrui@macklin.cn
QQ: 2885703204/285395191
微信: 19863730987/13918391375
现货供应
产品名: Phthalazinone pyrazole 去供应商网站查看 询盘CAS: 880487-62-7
产地: 上海
规格: 98%
价格: 5mg 650,10mg 1100,25mg 2000,100mg 6000
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: Phthalazinone pyrazole 98% MedMol 货号：S88209
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